Sometime in early May 1942 – according to a few survivors, on May 4 – the Germans and their collaborators surrounded the Dokszyce Ghetto, forcing the Jews (except for the numerous inmates who had managed to hide) into a club building. Many Jews were killed by the police and Gendarmerie on the spot, immediately upon arrest; some sick and elderly inmates were killed in their beds. At the club building, the collaborationist policemen carried out a selection. 350-400 Jews, rejected as unfit for work, were murdered at the same sand quarry. After the operation, the Germans reduced the ghetto area. Following this second massacre, the survivors began to build underground shelters, hoping to hide during the next mass murder, which they felt to be imminent.
On May 29, 1942, the Dokszyce Ghetto was liquidated, and the extermination of its population began. As before, the Germans (the security police and Gendarmerie) and local policemen surrounded the ghetto in the morning. This time, most of the ghetto Jews had gone into hiding, and some of their shelters and bunkers were rather sophisticated. For this reason, the murder operation dragged on for 17 days (instead of the expected single day), as the Nazis combed through the ghetto in search of the victims. According to survivors' accounts, when the Germans entered the ghetto, they were met only by the members of the Jewish council (Judenrat), while the rest of the inmates had hidden themselves. All those found in the ghetto throughout the lengthy search would be escorted to the sand quarry, forced to undress, and shot. The auxiliary police played an active role in the massacre. According to German reports, 2,653 Jews were killed in the course of this operation.