
In September 1939, World War II began, and Parafianów was annexed to the USSR. The Soviet authorities nationalized the sawmills and the other businesses, and closed down the Tarbut school. However, quite a few Jews managed to find employment in the new Soviet administrative apparatus. Aharon Lewitan became chairman of the local Soviet (council). Some young people left Parafianów to study in larger towns.
In June 1941, the Soviet-German War broke out, and the Germans had occupied Parafianów by the end of that month. Aharon Lewitan, who had been unable to flee, was betrayed by the locals, and the Germans shot him and displayed his dead body in the market square. Forced labor was introduced for all Jews over the age of 12, and various anti-Jewish orders and "ransom payments" in money and in kind (valuables, boots, leather, and fur) followed. A Jewish council was set up. In late 1941, a ghetto was established in Parafianów.
On May 29, 1942, the Nazis liquidated the ghetto, and all of its 500-600 inmates were shot at the town's garbage dump. Some Jews managed to escape from the ghetto, and even from the murder site, and survived.
Parafianów was liberated by the Red Army on July 2, 1944.