In August 1941, following the outbreak of the Soviet-German War and the arrival of Romanian troops in Rashkov, the new authorities compiled a list of over 300 Jews who were still in the town. All Jewish men were required by the Romanian authorities to perform forced labor of various kinds. Shortly afterward, Romanian gendarmes committed two massacres of Jewish men from Rashkov. On August 4, about 65 men were driven into the Dniester River and shot dead. On August 17, a second group of 34-38 Jewish males were also shot in the Dniester River. The Jewish women and children of Rashkov were deported to the town of Camenca, and subsequently to other camps in Transnistria.
In May 1942, several Jewish families who had been found hiding in the town and its vicinity were shot in the Dniester River by Romanian gendarmes.
Rashkov was liberated by the Red Army on March 24, 1944.