Germans troops captured Luboml on June 25, 1941. Upon their arrival, the Germans set fire to the center of the town, where most of the Jews were living. Shortly afterwards the Jews were required to wear white armbands bearing a blue Star of David (replaced in September by a yellow badge). A curfew was imposed on the Jews and the German authorities demanded that the Jews hand over all their gold objects and other valuables or be killed. During this period a Judenrat (Jewish council), headed by Kalman Kopelzon, was established and a Jewish police force was set up. On July 22 a German unit shot to death several hundred Jewish men near the Jewish cemetery outside the town. Another murder operation was carried out on August 21, 1941 when several hundred Jews, mostly women and elderly people, were shot to death in the Borki Forest outside of town. At the end of the same month the Germans forced some Jewish women to publicly burn scrolls of the Torah. After those two murder operations the German authorities ordered the Jews to hand over all their livestock to the German army. The Germans also constantly demanded "contributions" of gold, leather boots, and currency. In November 1941 the Jews of Luboml were forced to live in a concentrated manner, on several of the town's streets. In December, on the order of Gebietskommissar (regional commissar) Uhde, the Jews were forced into a two-part ghetto: one part was reserved for skilled workers and their families, while the other was designated for the rest of the town's Jews. The Jews in the ghetto were required to pay the "taxes" levied on them and were conscripted for forced labor.
On October 1, 1942 the Germans began the liquidation of the ghetto. According to a Soviet ChGK document 1,700 Jews were shot to death on that day at the former brick factory near Borki village. The murder operation lasted about a week since many Jews initially escaped the murder operation or hid in bunkers and various other prepared hideouts before they were caught. Only a few managed to escape to the forest to join the partisans.
Luboml was liberated by the Red Army on July 19, 1944.