
The Jews of Pereyaslav suffered greatly from the violence accompanying the years of revolution and civil war in Russia. In 1919 several pogroms were carried out in Pereyaslav by armed gangs.
In the 1920s and 1930s there was a four-(later a seven-) year Yiddish school in Pereyaslav. Pereyaslav was the birthplace of one of the founding fathers of modern Yiddish literature, Sholom Aleichem (Solomon Rabinovich). In the 1920s the home where Sholom Aleichem was born was turned into a museuem devoted to this writer.
In 1939 Pereiaslav's 937 Jews constituted 11.3 percent of town's total population.
German troops occupied Pereyaslav on September 17, 1941. Most of the local Jews, including Jewish women with Ukrainian husbands, were murdered on the town's outskirts in 1941-1943.
The Red Army liberated Pereyaslav on September 22, 1943. Right after the liberation the town was renamed Pereyaslav-Khmelnitsky, in honor of the leader of the Cossack uprising of 1648-1649.