Ruzhin was occupied by German troops on July 16, 1941. From the first days of the occupation the Jews were abused and had to perform forced labor, as well as to wear special round yellow patches on their chests and backs. The first mass murder of local Jews was carried out in September 1941. Only Jewish specialists and their families were left alive. The following day a ghetto was set up in the village and all Jews were settled in twelve houses surrounded by barbed wire. Jews from nearby villages were taken to Ruzhin to be incarcerated in the ghetto there. The total number of ghetto inmates was about 500. Jewish craftsmen, such as tailors, shoemakers, and barrel makers, were forced to work for the Germans. The rest of the inmates were used for less specialized jobs. The second mass murder took place in early May 1942, when most of the family members of the artisans were killed. The remaining Jews continued to live in the ghetto but then were killed in small groups. Thus, groups of Jews from Ruzhin and from nearby villages were murdered in July (according to another source in October 1942). The last murder operation was carried out either at the end of 1942 or in September 1943, in the vicinity of Balamutovka village.
Ruzhin was liberated by the Red Army on December 28, 1943.