German troops occupied Krymno on June 29, 1941. In May 1942, on the orders of Arno Kampf, the Gebietskommissar (regional commissar) of Kowel, the Jews of Krymno, Lubosziny, and other nearby villages were confined to a ghetto that was guarded by Ukrainian auxiliary policemen. A group of several dozen Jews with skills considered useful by the Germans were sent to the nearby village of Zabłocie.
On September 6, 1942 the inmates of the ghetto, mainly women, children, and elderly people, were taken outside the village and shot to death. In January 1943 a group of skilled Jewish workers from Krymno was shot to death, along with Jews from Zabłocie and nearby localities, near the village of Tur.
Krymno was liberated by the Red Army on April 16, 1944.