In August 1941 the members of Police Regiment South shot to death hundreds of local Jews in the forest outside the town.
After this murder operation a ghetto, comprising about 20 homes and surrounded with barbed wire, was set up in the old part of the town for the remaining Jews and ones from the town of Belogorodka and other nearby localities. The Germans appointed Avraham Minevich as Jewish elder. Overcrowding and starvation in the ghetto contributed to a high mortality rate. Apparently in June 1942, during the liquidation of the ghetto, the inmates were shot to death in the forest near Soshnoye village. A group of skilled workers was allowed to remain in the town in one building.
In the fall of 1942 several Jews who had managed to hide during the June murder operation were taken by Ukrainian policemen and shot to death at the same murder site. On January 1 or 2, 1943 the last remaining Jews in Izyaslav, the "specialists," were murdered at the site as well. Izyaslav was liberated by the Red Army on February 28, 1944.